Welcome
The JHU SNP Center is a high through-put genotyping facility featuring Illumina's BeadArrayTMtechnology, serving JHU and the scientific community at large.
The BeadArrayTMtechnology is a robust, flexible system which enables the analysis of a large number (1,000's) of genotypes using a relatively small quantity of DNA. The BeadLabTMcombines robotics, high-multiplex assays protocols, multi-array matrices, scanning instruments, LIMS, and automated allele-calling software to deliver high-confidence, highly accurate genotypes.
The technology takes advantage of the ability to bind 3-micron beads coated with hundreds of thousands of copies of a single-stranded nucleotide sequence onto acid-etched fiber optic bundles or glass slides. Each bundle holds up to 50,000 individual beads, each of which can assay a different SNP, up to 1,500 different SNPs on a single bundle. The glass slides can be arranged into a variety of different formats, including 12 sample formats assaying up to 60,000 SNPs per stripe or single sample formats assaying over 650,000 SNPs per slide.